4:30PM New York – U.S. stocks fell after retailers lowered the profit outlook and reported weaker than expected sales.

Of the stocks in S&P 500 index, 190 declined, 304 increased and 6 were unchanged.

Manitowoc Company led decliners in the S&P 500 index followed by losses in Sun Microsystems of 8.3%, in Wal-Mart Stores of 7.5%, in Nasdaq OMX Group of 7.4%, in CIT Group Inc 7.2%, in Limited Brands of 6.5%, in Intuitive Surgical of 6.2%, in Lincoln National Corp of 5.4%.

Sears Holdings led the gainers in S&P 500 index with a rise of 23% followed by increase in Whole Foods Market of 22.3%, in GameStop of Corp of 13%, in MBIA Inc of 11.5% and in AK Steel Holdings of 11%.

Other Movers

Abercrombie & Fitch Co (ANF) declined 9.5% or $2.26 to $21.48 after the specialty retailer of casual apparel reported 24% decrease in same-store sales for December, with 18% decline in net sales. Net sales for December totaled $539.2 million, down from $657.0 million in the same period of last year.

Anadys Pharmaceuticals, Inc (ANDS) climbed 64.4% or $1.23 to $3.14 after the drug developer said eight patients with hepatitis C treated with a twice-daily dose of the drug ANA598 reported a median reduction of more than 99% in the level of virus after three days of treatment.

Bed Bath & Beyond Inc (BBBY) slid 3.1% or 80 cents to $24.75 after the chain of retail stores said third quarter sales fell 0.6% to $1.78 billion from $1.79 billion a year ago. Net income in the quarter fell 36.5% to $87.7 million or 34 cents per diluted share compared to net income of $138.2 million or 52 cents per share a year ago.

FCStone Group, Inc (FCSX) rose 12.8% or 65 cents to $5.47 after the commodity risk management firm reported first quarter sales rose 16.3% to $85.6 million from $73.6 million a year ago. Net loss in the quarter was $3.0 million or 11 cents per diluted share compared to net income of $13.1 million or 45 cents per share a year ago.

GameStop Corp (GME) gained 8.7% or $1.97 to $24.58 after the world’s largest video-game retailer of raised its fourth quarter earning per share guidance from a range of $1.29 and $1.34 to $1.31 and $1.34.

Hansen Medical, Inc (HNSN) lost 21.9% or $1.73 to $6.12 after the medical company was downgraded to “underweight” from “equal weight” by analysts at Morgan Stanley.

Helen of Troy Limited (HELE) fell 13.4% or $1.98 to $12.75 after the worldwide marketer of brand-name personal care and household consumer products reported third quarter sales fell 11.8% to $185.62 million from $210.35 million a year ago. Net income in the quarter fell 34% to $15.09 million or 48 cents per diluted share compared to net income of $22.84 million or 73 cents per share a year ago.

Immucor, Inc (BLUD)) gained 9.5% or $2.25 to $25.75 after the maker of testing systems used by blood banks aid price increases in the United States accounted for nearly two-thirds of the rise in consolidated revenue, reported a rise of 7.3% in second quarter net income at $17.3 million. Revenue rose 18% to $73 million.

Intuitive Surgical, Inc (ISRG) fell 12.2% or $14.38 to $103.50 after the da Vinci Surgical Systems For 2009, the company expects revenue to increase about 15% over expected 2008 sales of about $875 million. Analysts on average expect the company to post revenue of $1.10 billion, according to Reuters Estimates.

Limited Brands, Inc (LTD) slipped 7.3% or 79 cents to $9.91 after the owner of the Victoria’s Secret chain the company currently estimates that fourth quarter earnings will be between 55 cents to 70 cents a share.

MSC Industrial Direct Co., Inc (MSM) plunged 10.8% or $3.91 to $31.98 after the tools and industrial services provider reported first quarter sales fell 1% to $433.0 million from $437.6 million a year ago. Net income in the quarter fell 4% to $45.1 million or 72 cents per diluted share compared to net income of $46.9 million or 70 cents per share a year ago.

The Manitowoc Company, Inc (MTW) slid 16.2% or $1.54 to $7.96 after the cranes and related products and foodservice equipment maker for full-year 2008 indicated that adjusted earnings will be within the low end of the previous guidance range of $3.15 to $3.25 per diluted share. For full year 2009, the company anticipates a revenue reduction of approximately 20% for its crane segment, which will be offset by an approximate 200% revenue increase by its foodservice segment.

Nordstrom, Inc (JWN) plunged 8.8% or $1.32 to $13.74 after the fashion specialty retailer reported preliminary sales of $1.13 billion for the five-week period ended January 3, 2009, down 8% from $1.22 billion for the five-week period ended January 5, 2008. Same-store sales for December decreased 10.6%.

The company now expects fourth-quarter earnings per share to not meet its previously announced outlook between $0.35 and $0.45.

Parametric Technology Corporation (PMTC) fell 14.1% or $1.82 to $11.03 after the maker of industrial software expects earnings of 14 cents a share to 16 cents a share, excluding items, on revenue of $240 million for the first quarter ended January 3.